Application

Monoamine Oxidase A has been used in a study to assess abnormal behavior in a large kindred of males where a deficiency of enzymatic activity of monamine oxidase A was found. It has also been used in a study to investigate an association between smoking and the inhibition of MAOA.

Biochem/physiol Actions

MAO′s are proteins of the mitochondrial membrane. These enzymes are responsible for catalyzing oxidative deamination of endo- and xenobiotic amines. Substrate specificity differs for each isozyme.

General description

Monoamine Oxidase A contains binding sites for 8α-S-cysteinyl-FAD.

Monoamine oxidases metabolize biogenic amines in the central nervous system and the peripheral tissue.